Construction and cryopreservation of an artificial ovary in cancer patients as an element of cancer therapy and a promising approach to fertility restoration

J Chen, P Todorov, E Isachenko, G Rahimi… - Human …, 2022 - Taylor & Francis
The proportion of cancer patients that survive is increasing because of improvements in
cancer therapy. However, some cancer treatments, such as chemo-and radio-therapies, can …

[HTML][HTML] Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data

K Oktay, L Marin, G Bedoschi, F Pacheco, Y Sugishita… - Fertility and sterility, 2022 - Elsevier
Objective To report our experience with robot-assisted (RA) autologous cryopreserved
ovarian tissue transplantation (ACOTT) with the use of a neovascularizing extracellular …

High cryo-resistance of SARS-CoV-2 virus: Increased risk of re-contamination at transplantation of cryopreserved ovarian tissue after COVID-19 pandemic

V Isachenko, E Isachenko, P Mallmann, G Rahimi - Cryobiology, 2021 - Elsevier
Cryopreservation and re-transplantation of ovarian tissue after anticancer treatment is
important medical technology. Today, during a pandemic, the risk of contamination of …

[HTML][HTML] Patient with ovarian insufficiency: baby born after anticancer therapy and re-transplantation of cryopreserved ovarian tissue

V Isachenko, B Morgenstern, P Todorov… - Journal of Ovarian …, 2020 - Springer
Background The second major cause of death is cancer. In fact, the effectiveness of
anticancer treatments and positive long-term prognosis for young women has increased …

[HTML][HTML] New method of FACS analyzing and sorting of intact whole ovarian fragments (COPAS) after long time (24 h) cooling to 5 C before cryopreservation

W Wang, M Salama, P Todorov, D Spitkovsky… - Cell and tissue …, 2021 - Springer
As recently announced by the American Society for Reproductive Medicine (ASRM), human
ovarian tissue cryopreservation is an established option for fertility preservation in …

[HTML][HTML] Model of micro-metastases of breast cancer cells in ovarian tissue: Cryopreservation of ZR-75-1 and MDA-MB-231 cells with increased speed of warming …

XX Du, P Todorov, E Isachenko, R Sanchez, P Uribe… - Cryobiology, 2024 - Elsevier
In medicine, ovarian tissue cryopreservation exists for fertility preservation of cancer
patients. In fact, ovarian tissue frozen for subsequent thawing and re-transplantation can be …

Assessment of molecular and morphological dynamics during long-time in vitro cultivation of cryopreserved human ovarian tissue: risk of genetic alterations

W Wang, P Todorov, E Isachenko, G Rahimi… - 2024 - researchsquare.com
Cryopreservation of human ovarian tissue is a technology for protection of reproductive
potential in patients undergoing aggressive anticancer treatments. This technology includes …

[HTML][HTML] Ovarian tissue freezing and activation after thawing: an update

L Peng - Middle East Fertility Society Journal, 2021 - Springer
Background With the growth of women's age, ovarian failure can be caused by various
factors. For the women who need chemotherapy because of cancer factors, the preservation …

[PDF][PDF] New method of FACS analyzing and sorting of intact whole ovarian fragments (COPAS) after long time (24 h) cooling to 5 C before cryopreservation

WWMSP Todorov, D Spitkovsky, EIRBG Rahimi… - unionbio.com
As recently announced by the American Society for Reproductive Medicine (ASRM), human
ovarian tissue cryopreservation is an established option for fertility preservation in …