The genetic toxicology of styrene and styrene oxide

R Barale - Mutation Research/Reviews in Genetic Toxicology, 1991 - Elsevier
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Development and validation of alternative metabolic systems for mutagenicity testing in short-term assays

J Rueff, C Chiapella, JK Chipman, F Darroudi… - Mutation Research …, 1996 - Elsevier
We present here the results obtained within the framework of an EU funded project aimed to
develop and validate alternative metabolic activating systems to be used in short-term …

Epoxidation of styrene by hemoglobin and myoglobin. Transfer of oxidizing equivalents to the protein surface.

PRO De Montellano, CE Catalano - Journal of Biological Chemistry, 1985 - Elsevier
Methemoglobin and metmyoglobin catalyze the H2O2-dependent oxidation of styrene to
styrene oxide and benzaldehyde. The formation of styrene oxide requires molecular oxygen …

Chromosome Damage Induced by Vinyl Acetate through in Vitro Formation of Acetaldehyde in Human Lymphocytes and Chinese Hamster Ovary Cells

H Norppa, F Tursi, P Pfäffli, J Mäki-Paakkanen… - Cancer research, 1985 - AACR
A 48-h treatment with vinyl acetate (0.05–1 mm) induced a drastic increase in sister
chromatid exchanges (SCEs) and (in first division cells) structural chromosome aberrations …

Metabolic activation of styrene by erythrocytes detected as increased sister chromatid exchanges in cultured human lymphocytes

H Norppa, H Vainio, M Sorsa - Cancer Research, 1983 - AACR
Styrene induces sister chromatid exchanges (SCEs) in human whole-blood lymphocyte
cultures without exogenous metabolizing systems, which indicates that styrene is …

A re-evaluation of the cytogenetic effects of styrene

D Scott, RJ Preston - Mutation Research/Reviews in Genetic Toxicology, 1994 - Elsevier
Results from new chromosome studies in laboratory animals, comparative investigations of
styrene metabolism and pharmacokinetics in humans and animals, and several recent …

[图书][B] Optimizaciones metodológicas del ensayo del cometa y su aplicación en biomonitorización humana

LA Zúñiga Venegas - 2009 - ddd.uab.cat
La integridad del DNA es un aspecto fundamental para la salud y el buen funcionamiento
de nuestro organismo. Sin embargo, sabemos que el material genético es susceptible de …

The Redox Potential of the β-93-Cysteine Thiol Group in Human Hemoglobin Estimated from In Vitro Oxidant Challenge Experiments

FM Rubino - Molecules, 2021 - mdpi.com
Glutathionyl hemoglobin is a minor form of hemoglobin with intriguing properties. The
measurement of the redox potential of its reactive β-93-Cysteine is useful to improve …

[图书][B] Review of the styrene assessment in the National toxicology program 12th report on carcinogens

National Research Council - 2014 - nap.nationalacademies.org
Review of the Styrene Assessment in the National Toxicology Program 12th Report on
Carcinogens | The National Academies Press Skip to main content Navigate to Help Ordering …

The human lymphocyte micronucleus assay: a comparison between whole-blood and separated-lymphocyte cultures

L Migliore, M Nieri, S Amodio, N Loprieno - Mutation Research Letters, 1989 - Elsevier
The induction of micronuclei (MN) by vincristine, mitomycin C and cyclophosphamide was
compared in purified lymphocytes and in whole-blood cultures. With both assays …