Insulin is produced by pancreatic β-cells, and once released to the blood, the hormone
stimulates glucose uptake and suppresses glucose production. Defects in both the …

Metabolic syndrome is known as a frequent precursor of type 2 diabetes mellitus (T2D). This
disease could affect 8% of the people worldwide. Given that pancreatic β‐cell dysfunction …

INTRODUCTION Insulin is secreted by pancreatic β cells in response to glucose stimulation.
Its release is controlled by the interplay of calcium and phosphoinositide signaling …

Pancreatic beta cells secrete insulin in response to stimulation with glucose and other
nutrients, and impaired insulin secretion plays a central role in development of diabetes …

Ca 2+ is an essential signal for pancreatic β-cell function. Ca 2+ plays critical roles in
numerous β-cell pathways such as insulin secretion, transcription, metabolism, endoplasmic …

Membrane contact sites (MCSs), regions where the membranes of two organelles are
closely apposed, play critical roles in inter-organelle communication, such as lipid trafficking …

Calcium ions (Ca2+) are major messengers in cell signaling, impacting nearly every aspect
of cellular life. Those signals are generated within a wide spatial and temporal range …

Insulin secretion from the β-cells of the islets of Langerhans is triggered mainly by nutrients
such as glucose, and incretin hormones such as glucagon-like peptide-1 (GLP-1). The …

SLC38A6 (SNAT6) is the only known member of the SLC38 family that is expressed
exclusively in the excitatory neurons of the brain. It has been described as an orphan …

Following stimulation, pancreatic β-cells must orchestrate a plethora of signalling events to
ensure the appropriate release of insulin and maintenance of normal glucose homeostasis …