Frequent platelet donation is associated with lymphopenia and risk of infections: a nationwide cohort study

J Zhao, E Gabriel, R Norda, P Höglund, L Baden… - …, 2021 - Wiley Online Library
Background Recently, plateletpheresis donations using a widely used leukoreduction
system (LRS) chamber have been associated with T‐cell lymphopenia. However, clinical …

Regular whole blood donation and gastrointestinal, breast, colorectal and haematological cancer risk among blood donors in Australia

MM Rahman, A Hayen, JK Olynyk, AE Cust… - Vox …, 2024 - Wiley Online Library
Abstract Background and Objectives Several studies have suggested that blood donors
have lower risk of gastrointestinal and breast cancers, whereas some have indicated an …

A methods review of the" healthy donor effect" in studies of long‐term health outcomes in blood donors.

MM Rahman, S Karki, A Hayen - Transfusion, 2022 - search.ebscohost.com
Peffer et al. first proposed the 10-year qualification period method (ie, all donors must have
donated for at least 10 years to be qualified for the study) as a means to adjust for HDE. 29 …

An iron rheostat controls hematopoietic stem cell fate

YR Kao, J Chen, R Kumari, A Ng, A Zintiridou… - Cell Stem Cell, 2024 - cell.com
Mechanisms governing the maintenance of blood-producing hematopoietic stem and
multipotent progenitor cells (HSPCs) are incompletely understood, particularly those …

The science… or not behind deferrals of blood donors with a history of cancer

RR Gammon, C Hopkins, G Mathur… - …, 2023 - Wiley Online Library
Abstract Background In the United States (US), each blood center's medical director sets
policy for donors with a cancer history. Study Design and Methods A subgroup of America's …

Association between Blood Donation and Malignant and Benign Tumour Risk: A Population‐Based Study of 3.4 Million Participants in China

S Su, T Ma, Y Sun, L Guo, X Su, W Wang… - Journal of …, 2022 - Wiley Online Library
This study aims to identify the relationship between blood donation and malignant and
benign tumour hospitalization risk. The cohort study was constructed in Shaanxi, China, to …

Clonal hematopoiesis in frequent whole blood donors

D Karpova - Hematology, 2023 - ashpublications.org
Healthy volunteer donors are committed to contributing key medical resources. Repeated,
regular donation of whole blood represents a specific trigger of hematopoietic stress …

[HTML][HTML] Exploration of the Healthy Donor Effect Among 0.6 Million Blood Donors in China: Longitudinal Study

S Su, Y Sun, X Gu, W Wu, X Su, T Ma… - JMIR Public Health …, 2024 - publichealth.jmir.org
Background: The World Health Organization emphasizes the importance of completely
voluntary blood donation to maintain safe and sustainable blood supplies. However, the …

High‐frequency whole blood donation and its impact on mortality: Evidence from a data linkage study in Australia

MM Rahman, S Karki, A Hayen - Transfusion, 2024 - Wiley Online Library
Background Previous reports suggest that blood donors have a lower mortality risk, which
may partially reflect the “healthy donor effect”(HDE). HDE arises in donors due to selection …

Frequent whole blood donations select for DNMT3A variants mediating enhanced response to erythropoietin

D Karpova, H Huerga Encabo, E Donato, I Kotova… - Blood, 2022 - ashpublications.org
Background Blood donation saves lives. Provided they are in good health, male volunteers
can donate as often as six times per year from the age of 18 into their late sixties. The …