It has been amply constated that sugar ligand multivalency increases lectin-binding avidities
dramatically, thereby modulating the capacity of carbohydrates to participate in …

Glycosidases are ubiquitous enzymes involved in a diversity of key biological processes
such as energy uptake or cell wall degradation. The design of specific glycosidase inhibitors …

The multivalent effect in glycosidase inhibition is a new topic in glycoscience that has
emerged a few years ago, with the discovery of neoglycoclusters displaying strong binding …

α-Mannosidosis (AM) results from deficient lysosomal α-mannosidase (LAMAN) activity and
subsequent substrate accumulation in the lysosome, leading to severe pathology. Many of …

Sialidases (SAs) hydrolyze sialyl residues from glycoconjugates of the eukaryotic cell
surface and are virulence factors expressed by pathogenic bacteria, viruses, and parasites …

With the increasingly mature research on protein-based multi-component systems at home
and abroad, the current research on protein-based functional systems has also become a …

Among carbohydrate-processing enzymes, Jack bean α-mannosidase (JBα-man) is the
glycosidase with the best responsiveness to the multivalent presentation of iminosugar …

Gold glyconanoparticles (Au GNPs) decorated with the natural iminosugar DAB-1 at different
densities are reported. These new multivalent iminosugar architectures strongly and …

Bambusurils, BU [4] and BU [6], were used for the first time as multivalent scaffolds to link
glycosidases inhibitors derived from 1-deoxynojirimycin (DNJ). Two linear DNJ ligands …

Carbohydrate-protein and carbohydrate-carbohydrate interactions are very important for
various biological processes. Although the magnitude of these interactions is low compared …