Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Uric acid is a waste product of purine catabolism. This molecule comes to clinical attention
when it nucleates to form crystals of monosodium urate (MSU) in joints or other tissues, and …

Multiple interacting checkpoints are involved in the pathophysiology of gout. Hyperuricemia
is the key risk factor for gout and is considered a prerequisite for monosodium urate (MSU) …

The tophus is the cardinal feature of advanced gout. This review summarises recent
research into the biology, impact and treatment of tophaceous gout. Microscopically, tophi …

Background The aim of this systematic literature review was to comprehensively describe
the anatomical pathology of tissues affected by gout. Methods We searched PubMed, The …

Objective To examine whether allopurinol dose escalation to achieve serum urate (SU)
target can influence bone erosion or monosodium urate (MSU) crystal deposition, as …

Objective To determine whether a therapeutic approach of intensive serum urate lowering
results in improved bone erosion scores in patients with erosive gout. Methods We …

Gout is a common form of inflammatory arthritis where urate crystals deposit in joints and
surrounding tissues. With the high prevalence of gout, the standardized and effective …

Background Gout is the most common inflammatory arthropathy of metabolic origin and it is
characterized by intense inflammation, the underlying mechanisms of which are unknown …

Objectives The aim of this work was to examine the relationship between joint damage and
monosodium urate (MSU) crystal deposition in gout. Methods Plain radiographs and dual …