Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Estimating the time of delivery is of high clinical importance because pre-and postterm
deviations are associated with complications for the mother and her offspring. However …

Background Normal pregnancy relies on a careful balance between immune tolerance and
suppression. It is known that strict regulation of maternal immune function, in addition to …

Birth is a physiological act that is part of the morpho-functional economy of the maternal
body. Each stage in the act of birth has a predetermined pathway that is neurohormonally …

Parturition is a well-orchestrated process characterized by increased uterine contractility,
cervical ripening, and activation of the chorioamniotic membranes; yet, the transition from a …

A successful human pregnancy requires precisely timed adaptations by the maternal
immune system to support fetal growth while simultaneously protecting mother and fetus …

Objective Uterine overdistention is thought to induce preterm labor in women with twin and
multiple pregnancies, but the pathophysiology remains unclear. We investigated for the first …

The signals and mechanisms that synchronize the timing of human parturition remain a
mystery and a better understanding of these processes is essential to avert adverse …

Our objective was to determine the amniotic fluid–derived exosomal proteomic profile in
patients who had spontaneous preterm birth (PTB) or preterm premature rupture of …