Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …

We performed an extensive immunogenomic analysis of more than 10,000 tumors
comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer …

We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …

Breast cancer is a heterogeneous disease with variable survival outcomes. Pathologists
grade the microscopic appearance of breast tissue using the Nottingham criteria, which are …

The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …

Background RNA-seq is widely used for transcriptomic profiling, but the bioinformatics
analysis of resultant data can be time-consuming and challenging, especially for biologists …

Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy
is key to developing new treatment strategies. Cancer-associated fibroblasts (CAF) have …

Summary The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of
diverse genomic alterations underlying human cancers. At this historic junction marking the …

Cancer development and its response to therapy are strongly influenced by innate and
adaptive immunity, which either promote or attenuate tumorigenesis and can have opposing …