Early brain injury after subarachnoid hemorrhage: incidence and mechanisms

DC Lauzier, K Jayaraman, JY Yuan, D Diwan… - Stroke, 2023 - Am Heart Assoc
Aneurysmal subarachnoid hemorrhage is a devastating condition causing significant
morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in …

Nanomedicine for brain cancer

S Quader, K Kataoka, H Cabral - Advanced Drug Delivery Reviews, 2022 - Elsevier
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

Z Liu, M Chopp - Progress in neurobiology, 2016 - Elsevier
Astrocytes are the most abundant cell type within the central nervous system. They play
essential roles in maintaining normal brain function, as they are a critical structural and …

Glial influence on the blood brain barrier

JI Alvarez, T Katayama, A Prat - Glia, 2013 - Wiley Online Library
The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central
nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB …

Pathogenesis of brain edema and investigation into anti-edema drugs

S Michinaga, Y Koyama - International journal of molecular sciences, 2015 - mdpi.com
Brain edema is a potentially fatal pathological state that occurs after brain injuries such as
stroke and head trauma. In the edematous brain, excess accumulation of extracellular fluid …

AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Nav1.6‐Mediated Astrocyte Autophagy

DD Zhu, YL Huang, SY Guo, N Li, XW Yang… - Advanced …, 2023 - Wiley Online Library
The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐
inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects …

The specific role of reactive astrocytes in stroke

L Li, J Zhou, L Han, X Wu, Y Shi, W Cui… - Frontiers in Cellular …, 2022 - frontiersin.org
Astrocytes are essential in maintaining normal brain functions such as blood brain barrier
(BBB) homeostasis and synapse formation as the most abundant cell type in the central …

Brain–immune interactions and neuroinflammation after traumatic brain injury

V Dinet, KG Petry, J Badaut - Frontiers in neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) is the principal cause of death and disability in children and
young adults. Clinical and preclinical research efforts have been carried out to understand …

Aquaporin and brain diseases

J Badaut, AM Fukuda, A Jullienne, KG Petry - Biochimica et Biophysica …, 2014 - Elsevier
Background The presence of water channel proteins, aquaporins (AQPs), in the brain led to
intense research in understanding the underlying roles of each of them under normal …

[HTML][HTML] Glial influences on BBB functions and molecular players in immune cell trafficking

MA Lecuyer, H Kebir, A Prat - … et Biophysica Acta (BBA)-Molecular Basis of …, 2016 - Elsevier
The blood–brain barrier (BBB) constitutes an elaborate structure formed by specialized
capillary endothelial cells, which together with pericytes and perivascular glial cells …