Neural stem cell-derived exosomes and regeneration: cell-free therapeutic strategies for traumatic brain injury

L Zhong, J Wang, P Wang, X Liu, P Liu… - Stem Cell Research & …, 2023 - Springer
Regenerative repair of the brain after traumatic brain injury (TBI) remains an extensive
clinical challenge, inspiring intensified interest in therapeutic approaches to explore superior …

Commonly overlooked factors in biocompatibility studies of neural implants

LS Kumosa - Advanced Science, 2023 - Wiley Online Library
Biocompatibility of cutting‐edge neural implants, surgical tools and techniques, and
therapeutic technologies is a challenging concept that can be easily misjudged. For …

Conversion of human urine-derived cells into neuron-like cells by small molecules

D Liu, G Rychkov, M Al-Hawwas, NPA Manaph… - Molecular Biology …, 2020 - Springer
Neural cell transplantation is an effective way for treatment of neurological diseases.
However, the absence of transplantable human neurons remains a barrier for clinical …

Dose-dependent modulation of microglia activation in rats after penetrating traumatic brain injury (pTBI) by transplanted human neural stem cells

ML Andreu, N Matti, HM Bramlett, Y Shi, S Gajavelli… - Plos one, 2023 - journals.plos.org
Traumatic brain injury (TBI) often results in long-lasting patterns of neurological deficits
including motor, sensory, and cognitive abnormalities. Cranial gunshot survivors are among …

Acid-ion sensing channel 1a deletion reduces chronic brain damage and neurological deficits after experimental traumatic brain injury

S Cheng, X Mao, X Lin, A Wehn, S Hu… - Journal of …, 2021 - liebertpub.com
Traumatic brain injury (TBI) causes long-lasting neurodegeneration and cognitive
impairments; however, the underlying mechanisms of these processes are not fully …

Human neural stem cell transplants to address multiple pathologies associated with traumatic brain injury

H Clervius, M Baig, A Mahavadi… - Neural Regeneration …, 2019 - journals.lww.com
Traumatic brain injury (TBI), an unmet need: TBI is an alteration in brain function caused by
an external force with evidence of brain pathology. It could be from a bump, blow, blast or jolt …

Emerging Approaches for Regenerative Rehabilitation Following Traumatic Brain Injury: Regenerative Rehabilitation in TBI

JC O'Donnell, RL Swanson, KL Wofford… - … : From Basic Science to …, 2022 - Springer
The potential for rehabilitation to improve recovery after traumatic brain injury (TBI) is limited
by a lack of inherent regenerative capacity in the brain as well as the chronic disabilities and …

Evolutionary conceptualization of the injury mechanisms intraumatic brain injury

DA Godoy, F Murillo-Cabezas - Medicina Intensiva (English Edition), 2022 - Elsevier
Conclusions In the pathophysiology of TBI, the concepts of tertiary and quaternary injuries
arise as new mechanisms of brain injury that should be taken into consideration for a holistic …

Injury-Transplantation Interval-Dependent Amelioration of Axonal Degeneration and Motor Deficit in Rats with Penetrating Traumatic Brain Injury

ML Andreu, LMQ Sanchez, MS Spurlock, Z Hu… - Neurotrauma …, 2023 - liebertpub.com
Penetrating traumatic brain injury (pTBI) is increasingly survivable, but permanently
disabling as adult mammalian nervous system does not regenerate. Recently, our group …

How neural stem cells promote the repair of brain injury through immunoregulation

C Jiang, BR Hou, ZN Wang, Y Chen, D Wang… - Chinese Medical …, 2020 - mednexus.org
Brain injury, such as traumatic brain injury and stroke, are important causes of death and
long-term disability all over the world.[1] Inflammation may play an essential role in …