Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Innate immune signaling and programmed cell death are intimately linked, and many
signaling pathways can regulate and induce both, transcription of inflammatory mediators or …

Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial
Parkinson's disease and is also linked to its idiopathic form. LRRK2 has been proposed to …

Interacting proteins tend to have similar functions, influencing the same organismal traits.
Interaction networks can be used to expand the list of candidate trait-associated genes from …

Objective Patients with Niemann–Pick disease type C1 (NPC1), a lysosomal lipid storage
disorder that causes neurodegeneration and liver damage, can present with IBD, but neither …

Despite progress in prostate cancer (PC) therapeutics, distant metastasis remains a major
cause of morbidity and mortality from PC. Thus, there is growing recognition that preventing …

Abstract Receptor Interacting Protein Kinases (RIPKs) are a family of Ser/Thr/Tyr kinases
whose functions, regulation and pathophysiologic roles have remained an enigma for a long …

Inflammatory responses mediated by NOD2 rely on RIP2 kinase and ubiquitin ligase XIAP
for the activation of nuclear factor κB (NF-κB), mitogen-activated protein kinases (MAPKs) …

The scaffolding function of receptor-interacting protein kinase 1 (RIPK1) regulates
prosurvival signaling and inflammatory gene expression, while its kinase activity mediates …

RIP2 kinase is a central component of the innate immune system and enables downstream
signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading …