Beyond R0 maximisation: on pathogen evolution and environmental dimensions

S Lion, JAJ Metz - Trends in ecology & evolution, 2018 - cell.com
A widespread tenet is that evolution of pathogens maximises their basic reproduction ratio,
R 0. The breakdown of this principle is typically discussed as exception. Here, we argue that …

The pluses and minuses of 0

MG Roberts - Journal of the Royal Society Interface, 2007 - royalsocietypublishing.org
The concept of the basic reproduction number (0) occupies a central place in epidemic
theory. The value of 0 determines the proportion of the population that becomes infected …

Global analysis of multi-strains SIS, SIR and MSIR epidemic models

D Bichara, A Iggidr, G Sallet - Journal of Applied Mathematics and …, 2014 - Springer
We consider SIS, SIR and MSIR models with standard mass action and varying population,
with n different pathogen strains of an infectious disease. We also consider the same models …

Strain replacement in an epidemic model with super-infection and perfect vaccination

M Iannelli, M Martcheva, XZ Li - Mathematical Biosciences, 2005 - Elsevier
Several articles in the recent literature discuss the complexities of the impact of vaccination
on competing subtypes of one micro-organism. Both with competing virus strains and …

Competitive exclusion and coexistence for pathogens in an epidemic model with variable population size

AS Ackleh, LJS Allen - Journal of mathematical biology, 2003 - Springer
We study an SIR epidemic model with a variable host population size. We prove that if the
model parameters satisfy certain inequalities then competition between n pathogens for a …

Hydrology and density feedbacks control the ecology of intermediate hosts of schistosomiasis across habitats in seasonal climates

J Perez-Saez, T Mande, N Ceperley… - Proceedings of the …, 2016 - National Acad Sciences
We report about field and theoretical studies on the ecology of the aquatic snails (Bulinus
spp. and Biomphalaria pfeifferi) that serve as obligate intermediate hosts in the complex life …

The dynamics of two viral infections in a single host population with applications to hantavirus

LJS Allen, M Langlais, CJ Phillips - Mathematical Biosciences, 2003 - Elsevier
An SI epidemic model for a host with two viral infections circulating within the population is
developed, analyzed, and numerically simulated. The model is a system of four differential …

On the evolutionary coexistence of parasite strains

A Pugliese - Mathematical biosciences, 2002 - Elsevier
Classical models of parasite competition show that coexistence is impossible if different
strains give complete cross-immunity. However, parasite coexistence is possible if some of …

Combination of survival movement strategies in cyclic game systems during an epidemic

E Rangel, B Moura, J Menezes - Biosystems, 2022 - Elsevier
Disease outbreaks affect many ecosystems threatening species that also fight against other
natural enemies. We investigate a cyclic game system with 5 species, whose organisms …

Pathogen evolution in finite populations: slow and steady spreads the best

TL Parsons, A Lambert, T Day… - Journal of The Royal …, 2018 - royalsocietypublishing.org
The theory of life-history evolution provides a powerful framework to understand the
evolutionary dynamics of pathogens. It assumes, however, that host populations are large …