Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

Autophagy is the process of cellular self-eating by a double-membrane organelle, the
autophagosome. A range of signaling processes converge on two protein complexes to …

Autophagy is a primarily degradative pathway that takes place in all eukaryotic cells. It is
used for recycling cytoplasm to generate macromolecular building blocks and energy under …

The year of 2013 marked the 50th anniversary of C de Duve's coining of the term
“autophagy” for the degradation process of cytoplasmic constituents in the …

Autophagy has burgeoned rapidly as a field of study because of its evolutionary
conservation, the diversity of intracellular cargoes degraded and recycled by this machinery …

Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a
portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically …

Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of
rapamycin), an evolutionarily-conserved protein kinase. TOR, as a central regulator of cell …

The Atg1/ULK1 complex plays a central role in starvation-induced autophagy, integrating
signals from upstream sensors such as MTOR and AMPK and transducing them to the …

The Atg1/ULK complex plays an essential role in the initiation of autophagy: receiving
signals of cellular nutrient status, recruiting downstream Atg proteins to the autophagosome …

The formation of the autophagosome, a landmark event in autophagy, is accomplished by
the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in …