[HTML][HTML] Platelet activation and thrombosis in COVID-19

T Iba, H Wada, JH Levy - Seminars in Thrombosis and …, 2023 - thieme-connect.com
Although thrombosis frequently occurs in infectious diseases, the coagulopathy associated
with COVID-19 has unique characteristics. Compared with bacterial sepsis, COVID-19 …

COVID-19 coagulopathy: from pathogenesis to treatment

T Alnima, MMG Mulder, BCT van Bussel… - Acta …, 2022 - karger.com
Abstract Coronavirus disease 2019 (COVID-19) has emerged as a pandemic at the end of
2019 and continues to exert an unfavorable worldwide health impact on a large proportion …

Biomarkers of endothelial dysfunction are associated with poor outcome in COVID‐19 patients: A systematic review and meta‐analysis

A Mohebbi, H Haybar… - Reviews in Medical …, 2023 - Wiley Online Library
Numerous studies have linked coronavirus disease 2019 (COVID‐19) with endothelial
dysfunction and reported elevated levels of endothelial biomarkers in this disease. We …

Effect of crizanlizumab, a P-selectin inhibitor, in COVID-19: a placebo-controlled, randomized trial

TM Leucker, WO Osburn, P Reventun, K Smith… - Basic to Translational …, 2021 - jacc.org
COVID-19 is characterized by vascular inflammation and thrombosis, including elevations in
P-selectin, a mediator of inflammation released by endothelial cells. We tested the effect of P …

[HTML][HTML] The role of P-selectin in COVID-19 coagulopathy: an updated review

C Agrati, A Sacchi, E Tartaglia, A Vergori… - International journal of …, 2021 - mdpi.com
In severe COVID-19, which is characterized by blood clots and neutrophil-platelet
aggregates in the circulating blood and different tissues, an increased incidence of …

It's in the blood: a review of the hematological system in SARS-CoV-2-associated COVID-19

JV Harte, C Coleman-Vaughan… - Critical Reviews in …, 2023 - Taylor & Francis
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led
to an unprecedented global healthcare crisis. While SARS-CoV-2-associated COVID-19 …

[HTML][HTML] Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives

MS Soltani-Zangbar, F Parhizkar, M Abdollahi… - Cell Communication and …, 2022 - Springer
Abstract During SARS-CoV-2 infection, an effective immune response provides the first line
of defense; however, excessive inflammatory innate immunity and impaired adaptive …

[HTML][HTML] Palmitoylethanolamide reduces proinflammatory markers in unvaccinated adults recently diagnosed with COVID-19: a randomized controlled trial

SN Fessler, L Liu, Y Chang, T Yip, CS Johnston - The Journal of nutrition, 2022 - Elsevier
Background Inflammation is at the core of many chronic conditions and exacerbates
infectious conditions, including the severity of coronavirus disease 2019 (COVID-19) …

Annexin A1 as a potential prognostic biomarker for COVID‐19 disease: Case–control study

O Canacik, R Sabirli, E Altintas, E Karsli… - … journal of clinical …, 2021 - Wiley Online Library
Abstract Background Annexin A1 (AnxA1) is an important endogenous glucocoticoid protein
that contributes to the suppression of inflammation by limiting the production of neutrophil …

Viral uptake and pathophysiology of the lung endothelial cells in age‐associated severe SARS‐CoV‐2 infection models

T Tsumita, R Takeda, N Maishi, Y Hida, M Sasaki… - Aging …, 2024 - Wiley Online Library
Thrombosis is the major cause of death in severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2) infection, and the pathology of vascular endothelial cells (ECs) has received …