Glymphatic system dysfunction and sleep disturbance may contribute to the pathogenesis and progression of Parkinson's disease

A Massey, MK Boag, A Magnier, DPCF Bispo… - International journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative
disease and the most prevalent neurodegenerative disorder after Alzheimer's disease with a …

The role of glymphatic system in Alzheimer's and Parkinson's disease pathogenesis

FR Buccellato, M D'Anca, M Serpente, A Arighi… - Biomedicines, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia, whilst
Parkinson's disease (PD) is a neurodegenerative movement disorder. These two …

Diffusion along perivascular spaces as marker for impairment of glymphatic system in Parkinson's disease

T Shen, Y Yue, F Ba, T He, X Tang, X Hu, J Pu… - npj Parkinson's …, 2022 - nature.com
The brain glymphatic system is involved in the clearance of misfolding α-synuclein, the
impaired glymphatic system may contribute to the progression of Parkinson's disease (PD) …

Diffusion tensor imaging along the perivascular space index in different stages of Parkinson's disease

X Ma, S Li, C Li, R Wang, M Chen, H Chen… - Frontiers in Aging …, 2021 - frontiersin.org
Background: The aim of this study was to evaluate the glymphatic system activity in patients
with Parkinson's disease (PD) using the diffusion tensor image analysis along the …

Glymphatic system dysfunction in obstructive sleep apnea evidenced by DTI-ALPS

HJ Lee, DA Lee, KJ Shin, KM Park - Sleep Medicine, 2022 - Elsevier
Objectives This study aimed to evaluate the glymphatic system function in patients with
obstructive sleep apnea (OSA) compared to healthy controls using diffusion tensor imaging …

Association of MRI indices of glymphatic system with amyloid deposition and cognition in mild cognitive impairment and Alzheimer disease

K Kamagata, C Andica, K Takabayashi, Y Saito… - Neurology, 2022 - AAN Enterprises
Background and Objectives The glymphatic system is a whole-brain perivascular network,
which promotes CSF/interstitial fluid exchange. Alterations to this system may play a pivotal …

Glymphatic dysfunction in patients with ischemic stroke

CH Toh, TY Siow - Frontiers in aging neuroscience, 2021 - frontiersin.org
Objectives: Rodent experiments have provided some insight into the changes of glymphatic
function in ischemic stroke. The diffusion tensor image analysis along the perivascular …

Neuroimaging uncovers distinct relationships of glymphatic dysfunction and motor symptoms in Parkinson's disease

Y Qin, R He, J Chen, X Zhou, X Zhou, Z Liu, Q Xu… - Journal of …, 2023 - Springer
Background Studies of glymphatic dysfunction in Parkinson's disease (PD) patients have
attracted much attention in recent years. However, the relationships between glymphatic …

[HTML][HTML] Imaging perivascular space structure and function using brain MRI

G Barisano, KM Lynch, F Sibilia, H Lan, NC Shih… - Neuroimage, 2022 - Elsevier
In this article, we provide an overview of current neuroimaging methods for studying
perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing …

Glymphatic dysfunction in isolated REM sleep behavior disorder

DA Lee, HJ Lee, KM Park - Acta Neurologica Scandinavica, 2022 - Wiley Online Library
Objectives This study aimed to evaluate glymphatic‐system function in patients with isolated
rapid eye movement sleep behavior disorder (iRBD) in comparison with healthy controls by …