Freezing of gait (FoG) is a disabling symptom characterized as a brief inability to step or by
short steps, which occurs when initiating gait or while turning, affecting over half the …

Background and objectives Freezing of gait (FOG) is a disabling gait disorder in patients
with Parkinson's disease (PD), characterized by recurrent episodes of halting steps …

Introduction Subthalamic deep-brain-stimulation (STN-DBS) is an effective means to treat
Parkinson's disease (PD) symptoms. Its benefit on gait disorders is variable, with freezing of …

Akinesia is a major manifestation of Parkinson's disease (PD) related to difficulties or failures
of willed movement to occur. Akinesia is still poorly understood and is not fully alleviated by …

While deep brain stimulation (DBS) in the subthalamic nucleus (STN) improves motor
functions in Parkinson's disease (PD), it may also increase impulsivity by interfering with the …

Deep brain stimulation (DBS) is a well-established treatment for both neurological and
psychiatric disorders. Directional DBS has the potential to minimize stimulation-induced side …

Introduction: Deep brain stimulation of the subthalamic nucleus is an effective therapy for the
motor symptoms of Parkinson's disease (PD). Typically, stimulation is applied at a high …

Abstract Background High frequency (130 Hz) subthalamic Deep-Brain-Stimulation (STN-
DBS) optimally improves cardinal motor symptoms in Parkinson disease (PD). Low …

Exploration of motor cortex activity is essential to understanding the pathophysiology in
Parkinson's Disease (PD), but only simple motor tasks can be investigated using a fMRI or …

Cognitive impairments and motor dysfunction are commonly observed behavioral
phenotypes in genetic animal models of neurodegenerative diseases. JNPL3 transgenic …