Inhibitors of the AAA+ chaperone p97
E Chapman, N Maksim, F De la Cruz, JJ La Clair - Molecules, 2015 - mdpi.com
It is remarkable that a pathway as ubiquitous as protein quality control can be targeted to
treat cancer. Bortezomib, an inhibitor of the proteasome, was first approved by the US Food …
treat cancer. Bortezomib, an inhibitor of the proteasome, was first approved by the US Food …
Inhibitors of the Sec61 complex and novel high throughput screening strategies to target the protein translocation pathway
E Pauwels, R Schülein, K Vermeire - International journal of molecular …, 2021 - mdpi.com
Proteins targeted to the secretory pathway start their intracellular journey by being
transported across biological membranes such as the endoplasmic reticulum (ER). A central …
transported across biological membranes such as the endoplasmic reticulum (ER). A central …
Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome
G Lopez-Castejon, NM Luheshi, V Compan… - Journal of Biological …, 2013 - ASBMB
IL-1β is a potent pro-inflammatory cytokine produced in response to infection or injury. It is
synthesized as an inactive precursor that is activated by the protease caspase-1 within a …
synthesized as an inactive precursor that is activated by the protease caspase-1 within a …
A cotranslational ubiquitination pathway for quality control of misfolded proteins
F Wang, LA Durfee, JM Huibregtse - Molecular cell, 2013 - cell.com
Previous studies have indicated that 6%–30% of newly synthesized proteins are rapidly
degraded by the ubiquitin-proteasome system; however, the relationship of ubiquitination to …
degraded by the ubiquitin-proteasome system; however, the relationship of ubiquitination to …
The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER
BS Hall, K Hill, M McKenna, J Ogbechi, S High… - PLoS …, 2014 - journals.plos.org
Infection with Mycobacterium ulcerans is characterised by tissue necrosis and
immunosuppression due to mycolactone, the necessary and sufficient virulence factor for …
immunosuppression due to mycolactone, the necessary and sufficient virulence factor for …
Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of …
J Ogbechi, BS Hall, T Sbarrato, J Taunton… - Cell death & …, 2018 - nature.com
Mycolactone is the exotoxin virulence factor of Mycobacterium ulcerans that causes the
neglected tropical disease Buruli ulcer. We recently showed it to be a broad spectrum …
neglected tropical disease Buruli ulcer. We recently showed it to be a broad spectrum …
Cellular turnover and degradation of the most common missense cystathionine beta‐synthase variants causing homocystinuria
Homocystinuria (HCU) due to cystathionine beta‐synthase (CBS) deficiency is the most
common inborn error of sulfur amino acid metabolism. Recent work suggests that missense …
common inborn error of sulfur amino acid metabolism. Recent work suggests that missense …
SUMO paralogue–specific functions revealed through systematic analysis of human knockout cell lines and gene expression data
The small ubiquitin-related modifiers (SUMOs) regulate nearly every aspect of cellular
function, from gene expression in the nucleus to ion transport at the plasma membrane. In …
function, from gene expression in the nucleus to ion transport at the plasma membrane. In …
Eeyarestatin compounds selectively enhance Sec61-mediated Ca2+ leakage from the endoplasmic reticulum
Summary Eeyarestatin 1 (ES1) inhibits p97-dependent protein degradation, Sec61-
dependent protein translocation into the endoplasmic reticulum (ER), and vesicular transport …
dependent protein translocation into the endoplasmic reticulum (ER), and vesicular transport …
Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents
V Van Puyenbroeck, K Vermeire - Cellular and Molecular Life Sciences, 2018 - Springer
Proteins routed to the secretory pathway start their journey by being transported across
biological membranes, such as the endoplasmic reticulum. The essential nature of this …
biological membranes, such as the endoplasmic reticulum. The essential nature of this …