The steep dependence of channel opening on membrane voltage allows voltage-dependent
K+ channels to turn on almost like a switch. Opening is driven by the movement of gating …

TRPM8, a member of the transient receptor potential family of ion channels, depolarizes
somatosensory neurons in response to cold. TRPM8 is also activated by the cooling agents …

Objectives: The aim of this study was to discern the role of the cardiac voltage-gated sodium
ion channel SCN5A in the etiology of dilated cardiomyopathy (DCM). Background: Dilated …

Voltage-gated ion channels share a common structure typified by peripheral, voltage sensor
domains. Their S4 segments respond to alteration in membrane potential with translocation …

All-atom molecular dynamics simulations are used to better understand the dynamic
environment experienced by the Kv1. 2 channel in a lipid membrane. The structure of the …

The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor
electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation …

The hERG channel has a relatively slow activation process but an extremely fast and voltage-
sensitive inactivation process. Direct measurement of hERG's gating current (Piper, DR, A …

Voltage-gated potassium channels (Kv channels) are the major determinants of cellular
repolarization in excitable cells-they open in response to depolarization and facilitate …

The transmembrane domains of HERG (S1–S3) contain six negative charges: three are
conserved in all voltage-gated K channels (D456 and D466 in S2, D501 in S3) and three are …

Abstract Episodic ataxia type1 (EA1) is an autosomal dominant disorder characterised by
episodes of ataxia, dysarthria, tremor and visual disturbances lasting for seconds or minutes …