Cellular senescence is a cell fate triggered in response to stress and is characterized by
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …

During vertebrate embryonic development, cellular senescence occurs at multiple locations.
To date, it has been accepted that when there has been induction of senescence in an …

Senescent cells accumulate throughout the body with advanced age, diseases and chronic
conditions. They negatively impact health and function of multiple systems, including the …

Biological sex is a factor in many conditions, including aging, neurodegenerative disease,
cancer, and more. For each of these, men and women display distinct differences in disease …

Mild traumatic brain injury (mTBI) is an important public health issue, as it can lead to long-
term neurological symptoms and risk of neurodegenerative disease. The pathophysiological …

Cellular senescence and the associated secretory phenotype (SASP) promote disease in
the aged population. Targeting senescent cells by means of removal, modulation of SASP or …

Introduction Chronic neuroinflammation can exist for months to years following traumatic
brain injury (TBI), although the underlying mechanisms remain poorly understood. Methods …

Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative
disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell …

Cellular senescence is a cell cycle arrest in damaged or aged cells. Although this represents
a critical mechanism of tumor suppression, persistence of senescent cells during aging …

Iron dyshomeostasis is a feature of Alzheimer's disease (AD). The impact of iron on AD is
attributed to its interactions with the central proteins of AD pathology (amyloid precursor …