Antibody–drug conjugates (ADCs) consist of cytotoxic drugs covalently linked to monoclonal
antibodies directed to antigens differentially overexpressed in tumor cells. These loaded …

Covering: up to the end of 2014 Fungi are widespread in nature and have conquered nearly
every ecological niche. Fungi occur not only in terrestrial but also in freshwater and marine …

Although microRNAs (miRNAs) are key regulators of gene expression in normal human
physiology and disease, transcriptional regulation of miRNAs is poorly understood, because …

HOTAIR is a long non-coding RNA that interacts with the polycomb repressive complex and
suppresses its target genes. HOTAIR has also been demonstrated to promote malignancy …

A conserved feature of the midblastula transition (MBT) is a requirement for a functional DNA
replication checkpoint to coordinate cell-cycle remodeling and zygotic genome activation …

Structural, biochemical, and genetic studies have led to proposals that a mobile element of
multisubunit RNA polymerases, the Trigger Loop (TL), plays a critical role in catalysis and …

To study how RNA polymerase II translocates after nucleotide incorporation, we prepared
elongation complex crystals in which pre-and post-translocation states interconvert. Crystal …

ABSTRACT TAR DNA-binding protein 43 (TDP-43; also known as TARDBP) is an RNA-
binding protein whose aggregation is a hallmark of the neurodegenerative disorders …

RNA polymerase (RNAP) is a complex molecular machine that governs gene expression
and its regulation in all cellular organisms. To accomplish its function of accurately …

Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main
lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment …