[HTML][HTML] It is the time for quorum sensing inhibition as alternative strategy of antimicrobial therapy

NG Naga, DE El-Badan, KM Ghanem… - Cell Communication and …, 2023 - Springer
Multiple drug resistance poses a significant threat to public health worldwide, with a
substantial increase in morbidity and mortality rates. Consequently, searching for novel …

Furanone quorum-sensing inhibitors with potential as novel therapeutics against Pseudomonas aeruginosa

CR Proctor, PA McCarron… - Journal of Medical …, 2020 - microbiologyresearch.org
Micro-organisms use quorum sensing (QS), a cell density-dependent process, to
communicate. This QS mode of interchange leads to the production of a variety of virulence …

Inhibition of Pseudomonas aeruginosa quorum sensing by methyl gallate from Mangifera indica

NG Naga, AA Zaki, DE El-Badan, HS Rateb… - Scientific Reports, 2023 - nature.com
Antipathogenic drugs are a potential source of therapeutics, particularly following the
emergence of multiple drug-resistant pathogenic microorganisms in the last decade. The …

Identification of novel candidates for inhibition of LasR, a quorum-sensing receptor of multidrug resistant Pseudomonas aeruginosa, through a specialized multi-level …

RP Magalhães, TF Vieira, A Melo… - Molecular Systems Design …, 2022 - pubs.rsc.org
The emergence of multi-drug resistant bacteria in the past decades has become one of the
major public health issues of our time. One of the main mechanisms of resistance and …

Assessing the Molecular Targets and Mode of Action of Furanone C-30 on Pseudomonas aeruginosa Quorum Sensing

V Markus, K Golberg, K Teralı, N Ozer… - Molecules, 2021 - mdpi.com
Quorum sensing (QS), a sophisticated system of bacterial communication that depends on
population density, is employed by many pathogenic bacteria to regulate virulence. In view …

Quorum Sensing Inhibiting Activity of Cefoperazone and Its Metallic Derivatives on Pseudomonas aeruginosa

NG Naga, DE El-Badan, HS Rateb… - Frontiers in Cellular …, 2021 - frontiersin.org
The last decade has witnessed a massive increase in the rate of mortalities caused by
multidrug-resistant Pseudomonas aeruginosa. Therefore, developing new strategies to …

[PDF][PDF] Evaluation of pharmacokinetic properties, toxicity, and bioactive cytotoxic activity of black rice (Oryza sativa L.) as candidates for diabetes mellitus drugs by in …

FK Hartati, AB Djauhari, VD Kharisma - Biointerface Res Appl Chem, 2021 - academia.edu
The in silico method is widely used to search for drug candidates, namely by predicting
physicochemical properties, pharmacokinetics (ADME), toxicity, know the description of drug …

[HTML][HTML] Inhibitory effects of artificial sweeteners on bacterial quorum sensing

V Markus, O Share, M Shagan, B Halpern… - International journal of …, 2021 - mdpi.com
Despite having been tagged as safe and beneficial, recent evidence remains inconclusive
regarding the status of artificial sweeteners and their putative effects on gut microbiota. Gut …

The effect of LuxR solo EvgA on the spoilage potential of Pseudomonas fluorescens

D Wang, B Zhang, Y Wang, L Ren, Y Meng, R Ma… - Food Bioscience, 2024 - Elsevier
LuxR solos sense exogenous signaling molecules and regulate microbial behaviors, thus
facilitating intra-and inter-species communication among bacteria. However, studies on the …

Docking and molecular dynamic of microalgae compounds as potential inhibitors of beta-lactamase

R Pestana-Nobles, Y Aranguren-Díaz… - International Journal of …, 2022 - mdpi.com
Bacterial resistance is responsible for a wide variety of health problems, both in children and
adults. The persistence of symptoms and infections are mainly treated with β-lactam …