Integrative biology of injury in animals

CW Rennolds, AE Bely - Biological Reviews, 2023 - Wiley Online Library
Mechanical injury is a prevalent challenge in the lives of animals with myriad potential
consequences for organisms, including reduced fitness and death. Research on animal …

Advancements to the axolotl model for regeneration and aging

WA Vieira, KM Wells, CD McCusker - Gerontology, 2020 - karger.com
Loss of regenerative capacity is a normal part of aging. However, some organisms, such as
the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover …

A tissue-mapped axolotl de novo transcriptome enables identification of limb regeneration factors

DM Bryant, K Johnson, T DiTommaso, T Tickle… - Cell reports, 2017 - cell.com
Mammals have extremely limited regenerative capabilities; however, axolotls are profoundly
regenerative and can replace entire limbs. The mechanisms underlying limb regeneration …

Positional memory in vertebrate regeneration: a century's insights from the salamander limb

L Otsuki, EM Tanaka - Cold Spring Harbor Perspectives …, 2022 - cshperspectives.cshlp.org
Salamanders, such as axolotls and newts, can regenerate complex tissues including entire
limbs. But what mechanisms ensure that an amputated limb regenerates a limb, and not a …

[HTML][HTML] FGF, BMP, and RA signaling are sufficient for the induction of complete limb regeneration from non-regenerating wounds on Ambystoma mexicanum limbs

WA Vieira, KM Wells, MJ Raymond, L De Souza… - Developmental …, 2019 - Elsevier
Some organisms, such as the Mexican axolotl, have the capacity to regenerate complicated
biological structures throughout their lives. Which molecular pathways are sufficient to …

Wound‐induced cell proliferation during animal regeneration

L Ricci, M Srivastava - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Many animal species are capable of replacing missing tissues that are lost upon injury or
amputation through the process of regeneration. Although the extent of regeneration is …

Cranial neural crest cells contribution to craniofacial bone development and regeneration

P Smeriglio, A Zalc - Current Osteoporosis Reports, 2023 - Springer
Abstract Purpose of Review This review aims to summarize (i) the latest evidence on cranial
neural crest cells (CNCC) contribution to craniofacial development and ossification;(ii) the …

Tig1 regulates proximo-distal identity during salamander limb regeneration

CR Oliveira, D Knapp, A Elewa, T Gerber… - nature …, 2022 - nature.com
Salamander limb regeneration is an accurate process which gives rise exclusively to the
missing structures, irrespective of the amputation level. This suggests that cells in the stump …

Making a new limb out of old cells: exploring endogenous cell reprogramming and its role during limb regeneration

MJ Raymond Jr, CD McCusker - American Journal of …, 2024 - journals.physiology.org
Cellular reprogramming is characterized by the induced dedifferentiation of mature cells into
a more plastic and potent state. This process can occur through artificial reprogramming …

Transcriptomic analysis of Portunus trituberculatus reveals a critical role for WNT4 and WNT signalling in limb regeneration

L Liu, Y Fu, F Zhu, C Mu, R Li, W Song, C Shi, Y Ye… - Gene, 2018 - Elsevier
The swimming crab (Portunus trituberculatus) is among the most economically important
seawater crustacean species in Asia. Despite its commercial importance and being well …