Despite the prevalence of opioid misuse, opioids remain the frontline treatment regimen for
severe pain. However, opioid safety is hampered by side-effects such as analgesic …

Ensuring high-quality, respectful, and appropriate management of chronic non-cancer pain
(CNCP) in the context of the US opioid crisis is a critical and complex endeavor. At the end …

The anterior cingulate cortex (ACC) is implicated in many pathologies, including depression,
anxiety, substance-use disorders, and pain. There is also evidence from brain imaging that …

Chronic pain is a major public health issue that frequently leads to analgesic opioid
prescriptions. These prescriptions could cause addiction issues in high-risk patients with …

Preclinical opioid research using animal models not only provides mechanistic insights into
the modulation of opioid analgesia and its associated side effects, but also validates drug …

Although opioids still remain the most powerful pain-killers, the chronic use of opioid
analgesics is largely limited by their numerous side-effects, including opioid dependence …

Sickle cell disease (SCD) is an inherited disorder of hemoglobin structure. The clinical
effects of the sickle gene are pleiotropic in nature causing multiple phenotypic expressions …

Opiate addiction is increasing and plaguing the western world and specifically the US It
takes a large toll on both a personal and societal level and carries a high cost. Withdrawal is …

Abstract In the United States, more than 100 million people suffer from chronic pain. Among
patients presenting for surgery, about one in four have chronic pain. Acute perioperative …

Background Untreated pain is a source of significant physical and psychosocial distress in
patients with cancer. While guidelines for prescribing opioids have improved the treatment of …