Finding strategies against the development of antibiotic resistance is a major global
challenge for the life sciences community and for public health. The past decades have seen …

Antimicrobial resistance (AMR) is a global threat to society due to the increasing emergence
of multi-drug resistant bacteria that are not susceptible to our last line of defence antibiotics …

Covering: up to the end of 2016 Novel antimicrobial drugs are continuously needed to
counteract bacterial resistance development. An innovative molecular design strategy for …

Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is
assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of …

Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from
Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have …

Avibactam, which is the first non-β-lactam β-lactamase inhibitor to be introduced for clinical
use, is a broad-spectrum serine β-lactamase inhibitor with activity against class A, class C …

Infections by Gram-negative pathogens represent a major health care issue of growing
concern due to a striking lack of novel antibacterial agents over the course of the last …

Introduction Several decades of antitubercular drug discovery efforts have focused on novel
antitubercular chemotherapies. However, recent efforts have greatly shifted toward …

The success of precision medicine coupled with the disappointing impact of broad-spectrum
antibiotic use on microbiome stability and bacterial resistance, has triggered a shift in …

Siderophores are low-molecular-weight chelators produced by microorganisms to scavenge
iron from the environment and deliver it to cells via specific receptors. Tremendous …