Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

Oxygen homeostasis represents an organizing principle for understanding metazoan
evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) …

Hypoxia is a feature of most tumours, albeit with variable incidence and severity within a
given patient population. It is a negative prognostic and predictive factor owing to its multiple …

The conversion of cells with an epithelial phenotype into cells with a mesenchymal
phenotype, referred to as epithelial–mesenchymal transition, is a critical process for …

Deletions and duplications of chromosomal segments (copy number variants, CNVs) are a
major source of variation between individual humans and are an underlying factor in human …

Areas of hypoxic tumour tissue are known to be resistant to treatment and are associated
with a poor clinical prognosis. There are several reasons why this might be, including the …

Chromosome structural changes with nonrecurrent endpoints associated with genomic
disorders offer windows into the mechanism of origin of copy number variation (CNV). A …

Most cancer deaths are due to the development of metastases, hence the most important
improvements in morbidity and mortality will result from prevention (or elimination) of such …

Hypoxia has been recognized as one of the fundamentally important features of solid tumors
and plays a critical role in various cellular and physiologic events, including cell …

Our concept of a stable genome is evolving to one in which genomes are plastic and
responsive to environmental changes. Growing evidence shows that a variety of …