Eukaryotic cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial
respiratory chain. COX is a multimeric enzyme formed by subunits of dual genetic origin …

There has been increasing evidence pointing to the mitochondrial respiratory chain (MRC)
as a novel and important target for the actions of 17β-estradiol (E2) and estrogen receptors …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

The mitochondrion is arguably the most complex organelle in the budding yeast cell
cytoplasm. It is essential for viability as well as respiratory growth. Its innermost aqueous …

Mitochondria are dynamic organelles of endosymbiotic origin that are essential components
of eukaryal cells. They contain their own genetic machinery, have multicopy genomes and …

Protein synthesis in mammalian mitochondria produces 13 proteins that are essential
subunits of the oxidative phosphorylation complexes. This review provides a detailed outline …

Mitochondrial disorders are a heterogeneous group of often multisystemic and early fatal
diseases, which are amongst the most common inherited human diseases. These disorders …

Mitochondria maintain genome and translation machinery to synthesize a small subset of
subunits of the oxidative phosphorylation system. To build up functional enzymes, these …

Mammalian complex I is composed of 44 different subunits and its assembly requires at
least 13 specific assembly factors. Proper function of the mitochondrial respiratory chain …

Mitochondrial function depends on the correct synthesis, transport, and assembly of proteins
and cofactors of the electron transport chain. The initial idea that the respiratory chain …