Comprehensive coverage on anti-mycobacterial endeavour reported during 2022

TM Dhameliya, DD Vekariya, HY Patel… - European Journal of …, 2023 - Elsevier
TB being one of the deadliest diseases and second most common infectious cause of
deaths, poses the severe threat to global health. The extended duration of therapy owing to …

Cytochrome bd oxidase: An emerging anti-tubercular drug target

P Saha, S Das, HK Indurthi, R Kumar, A Roy… - RSC Medicinal …, 2024 - pubs.rsc.org
Cytochrome bd (Cyt-bd) oxidase, one of the two terminal oxidases in the Mycobacterium
tuberculosis (Mtb) oxidative phosphorylation pathway, plays an indispensable role in …

Efficient synthesis and molecular docking analysis of quinazoline and azole hybrid derivatives as promising agents for anti-cancer and anti-tuberculosis activities

G Kumar, P Kumar, A Soni, V Sharma… - Journal of Molecular …, 2024 - Elsevier
Molecular docking is a computational method based on bioinformatics that simulates the
interaction dynamics of molecules such as ligands and receptors, predicting their binding …

Targeting Tuberculosis: Novel Scaffolds for Inhibiting Cytochrome bd Oxidase

C Seitz, SH Ahn, H Wei, M Kyte, GM Cook… - Journal of Chemical …, 2024 - ACS Publications
Discovered in the 1920s, cytochrome bd is a terminal oxidase that has received renewed
attention as a drug target since its atomic structure was first determined in 2016. Only found …

Studies on Methylpyrazole-Substituted Benzimidazoles to Target Helicobacter pylori Infection through HpIMPDH Inhibition

H Dilip, V Thiruvenkatam… - ACS Infectious Diseases, 2024 - ACS Publications
The prevalence of Helicobacter pylori infection has been increasing rapidly due to the
genetic heterogeneity and antibacterial resistance shown by the bacteria, affecting over 50 …

One-pot synthesis of N-acylated ureas using phenyliodine (III) diacetate (PIDA) as N-acylation agent

R Feng, L Huang, DB Qin, F Zhou, ZB Dong - Tetrahedron Letters, 2023 - Elsevier
An effective method was explored for the one-pot synthesis of N-acylated urea derivatives by
the reaction of substituted isothiocyanatobenzenes, primary amines and PIDA (phenyliodine …

N-Substituted (Hexahydro)-1H-isoindole-1,3(2H)-dione Derivatives: New Insights into Synthesis and Characterization

CD Bădiceanu, C Mares, DC Nuță, S Avram… - Processes, 2023 - mdpi.com
Novel phthalimide derivatives, namely N-(1, 3-dioxoisoindolin-2-yl)-2-(2-methyl-4-
oxoquinazolin-3 (4 H)-yl) acetamide (1a) and N-(1, 3-dioxoisoindolin-2-yl) thiophene-2 …

[PDF][PDF] Design, Synthesis, Molecular Docking, In-vitro Anticancer and Antibacterial Evaluation of Novel Pyrazole Linked with Quinazoline Scaffolds.

M AFRO, G SHIvA kUMAR - Oriental Journal of Chemistry, 2023 - pdfs.semanticscholar.org
Design, Synthesis, Molecular Docking, In-vitro Anticancer and Antibacterial Evaluation of Novel
Pyrazole Linked with Quinazoline Page 1 ORIENTAL JOURNAL OF CHEMISTRY …