Most members of the large ATP-binding cassette (ABC) gene family are transporters
involved in substrate translocation across biological membranes. In eukaryotes, ABC …

Zebrafish are becoming increasingly popular as an organism in which to model human
disease and to study the effects of small molecules on complex physiological and …

Glycans are essential for the maintenance of normal biological function, with alterations in
glycan expression being a hallmark of cancer. Cancer stem cells (CSCs) are a subset of …

Drug transporters are integral membrane proteins that play a critical role in drug disposition
by affecting absorption, distribution, and excretion. They translocate drugs, as well as …

Background/Aim: The ATP-binding cassette subfamily B member 5 (ABCB5) transporter
plays a pivotal role in melanocyte progenitor cell fusion and has been identified as a tumor …

Background Although a large set of full-length transcripts was recently assembled in catfish,
annotation of large gene families, especially those with duplications, is still a great …

Abstract Since over 50 years, 5-fluorouracil (5-FU) is in use as backbone of chemotherapy
treatment regimens for a wide range of cancers including colon, breast, and head and neck …

Growing evidence suggests that the cancer stem cell phenotype in melanoma is dynamically
regulated. Therefore, effective therapies have to target simultaneously bulk tumor cells and …

Recent research has revealed that ion channels and transporters can be important players
in tumor development, progression, and therapy resistance in melanoma. For example …

Distinct ABCB5 forms and ABCF2, members of the ATP-binding cassette (ABC) superfamily
of transporters, are normally expressed in various tissues and cells, and enhanced …