According to the World Health Organization (WHO), 422 million people are suffering from
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …

Small molecule kinase inhibitors (SMKIs) are of heightened interest in the field of drug
research and development. There are 79 (as of July 2023) small molecule kinase inhibitors …

Determining the three-dimensional structure of proteins in their native functional states has
been a longstanding challenge in structural biology. While integrative structural biology has …

Protein kinase function and interactions with drugs are controlled in part by the movement of
the DFG and ɑC-Helix motifs that are related to the catalytic activity of the kinase. Small …

Protein kinases are dynamic, adopting different conformational states that are critical for their
catalytic activity. We assess a range of structural features derived from the conserved αC …

Colorectal cancer is the third most common malignancy in men and the second most
common cancer in women. Despite the success of screening programs and the …

Protein kinases are one of the most targeted protein families in current drug discovery
pipelines. They are implicated in many oncological, inflammatory, CNS-related and other …

Drug-based strategies to overcome tumour resistance to radiotherapy (R-RT) remain limited
by the single-agent toxicity of traditional radiosensitizers (for example, platinums) and a lack …

Polysaccharide lyases (PLs) are enzymes that our commonly used by microorganisms to
degrade polyuronides. These enzymes are produced by bacteria to aid in reducing the high …

Highlights•Studying biomolecular folding with optical tweezers grants high dynamic
range.•Combining optical tweezers with molecular dynamics simulation enables accurate …