Bone remodeling replaces old and damaged bone with new bone through a sequence of
cellular events occurring on the same surface without any change in bone shape. It was …

Cellular and molecular aging biomarkers might contribute to identify at-risk individuals for
frailty before overt clinical manifestations appear. Although studies on the associations of …

The term “frailty” is used to describe a subset of older adults who appear weaker and more
vulnerable than their age-matched counterparts, despite having similar comorbidities …

The Geroscience aims at a better understanding of the biological processes of aging, to
prevent and/or delay the onset of chronic diseases and disability as well as to reduce the …

Background Repair of large-sized bone defects is a challengeable obstacle in orthopedics
and evoked the demand for the development of biomaterials that could induce bone repair …

Various biomaterials have been evaluated to enhance bone formation in critical-sized bone
defects; however, the ideal scaffold is still missing. The objective of this study was to …

The locomotor system comprises skeletal muscles and bones with active metabolism and
cellular turnover. Chronic locomotor system disorders gradually arising with aging are …

Aging of the global population increases the incidence of osteoporosis and associated
fragility fractures, significantly impacting patient quality of life and healthcare costs. The …

Simple Summary The interactions between cancer cells and the surrounding blood vessels
and peripheral nerves are critical in all the phases of tumor development. Accordingly …

Lamin A/C, intermediate filament proteins from the nuclear lamina encoded by the LMNA
gene, play a central role in mediating the mechanosignaling of cytoskeletal forces into …