Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a
biologically uncontrolled process, whereas RCD involves tightly structured signaling …

Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …

Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …

Some forms of regulated cell death, such as apoptosis, are precipitated by the activation of
cysteine proteases of the caspase family, including caspase 8, 9, and 3. Other caspases …

Targeted manipulation of the gut flora is increasingly being recognized as a means to
improve human health. Yet, the temporal dynamics and intra-and interindividual …

Enteric-associated neurons (EANs) are closely associated with immune cells and
continuously monitor and modulate homeostatic intestinal functions, including motility and …

The International Knockout Mouse Consortium (IKMC) introduces its targeted constructs into
C57BL/6N embryonic stem cells. However, breeding with a Cre-recombinase and/or Flp …