The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM)
macromolecules filled with a collection of cells including cancer-associated fibroblasts …

ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well.
Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which …

Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its
most common histological subtype. Clinical and molecular evidence indicates that lung …

Cells respond to both chemical and mechanical cues present within their microenvironment.
Various mechanical signals are detected by and transmitted to the cells through …

Summary The phosphatidylinositol 3′ kinase (PI3′ K) pathway, which regulates cell
survival, is antagonized by the PTEN tumor suppressor. The regulation of PTEN is unclear. A …

Expansion of plastic-adherent bone marrow-derived mesenchymal stem cells (MSCs)
results in gradual loss of osteogenic potential after passage 5–6. One explanation is …

A method of treating a patient who has non-small cell lung carcinoma (NSCLC), lung cancer,
gastric cancer, and/or glioblastoma includes administering to said patient a composition …

Integrin α11β1 is a stromal cell-specific receptor for fibrillar collagens and is overexpressed
in carcinoma-associated fibroblasts (CAFs). We have investigated its direct role in cancer …

The present invention relates to peptides, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …