In this in-depth review, we examine the worldwide epidemiology of SLE and summarize
current knowledge on the influence of race/ethnicity on clinical manifestations, disease …

Introduction: Systemic lupus erythematosus (SLE) is a disease distributed worldwide, which
occurs in both genders, and across racial/ethnic and age groups; however, higher rates are …

Objective To study the effect of renal disease on the standardized mortality ratio (SMR) and
life expectancy of patients with systemic lupus erythematosus (SLE). Methods Patients …

Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease,
represents a significant challenge for both diagnosis and treatment. Patients with SLE in …

The genome-wide association study is a free-hypothesis approach based on screening of
thousands or even millions of genetic variants distributed throughout the whole human …

Background A primary characteristic of complex genetic diseases is that affected individuals
tend to cluster in families (that is, familial aggregation). Aggregation of the same …

Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a
strong genetic component. We undertook the present work to perform the first genome‐wide …

Ethnicity is a biological and a social construct which encompasses ancestral genes, cultural,
geographic and socioeconomic characteristics shared within a population. It is clear that no …

Progress in defining the genetics of autoimmune disease has been dramatically enhanced
by large scale genetic studies. Genome-wide approaches, examining hundreds or for some …

The need for comprehensive published epidemiologic and clinical data from Latin American
systemic lupus erythematosus (SLE) patients motivated the late Dr Alarcón-Segovia and …