[HTML][HTML] Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies

C Yao, S Dai, C Wang, K Fu, R Wu, X Zhao… - Biomedicine & …, 2023 - Elsevier
Luteolin is a flavonoid widely present in various traditional Chinese medicines. In recent
years, luteolin has received more attention due to its impressive liver protective effect, such …

Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway

S Mahdiani, N Omidkhoda, S Heidari, AW Hayes… - Biofactors, 2022 - Wiley Online Library
Humans are continuously exposed to environmental, occupational, consumer and
household products, food, and pharmaceutical substances. Luteolin, a flavone from the …

Renoprotective effects of luteolin: Therapeutic potential for COVID-19-associated acute kidney injuries

LRL Diniz, HA Elshabrawy, MTS Souza, ABS Duarte… - Biomolecules, 2022 - mdpi.com
Acute kidney injury (AKI) has been increasingly reported in critically-ill COVID-19 patients.
Moreover, there was significant positive correlation between COVID-19 deaths and renal …

[HTML][HTML] Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis

G Manda, E Milanesi, S Genc, CM Niculite… - Free Radical Biology …, 2022 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease with an important inflammatory
component accompanied by deregulated redox-dependent signaling pathways that are …

Cross-linker engineered poly (hydroxyethyl methacrylate) hydrogel allows photodynamic and photothermal therapies and controlled drug release

MP Algi, R Sarıgöl - European Journal of Pharmaceutics and …, 2024 - Elsevier
Here, we disclose the synthesis of poly (2-hydroxyethyl methacrylate)(PHEMA) hydrogels
incorporating a squaraine dye (Sq) as a chemical crosslinker, viz. Sq@ PHEMA …

Protective effect of pycnogenol against methotrexate-induced hepatic, renal, and cardiac toxicity: An in vivo study

F Al-Abkal, BA Abdel-Wahab, HFA El-Kareem… - Pharmaceuticals, 2022 - mdpi.com
Methotrexate (MTX) is one of the most commonly used chemotherapies for various types of
cancer, including leukemia, breast cancer, hepatocarcinoma, and gastric cancers. However …

Spirulina and thymoquinone protect against methotrexate-induced hepatic injury in rats

A Behairy, A Elkomy, F Elsayed, MMS Gaballa… - Revista Brasileira de …, 2024 - Springer
Methotrexate is a chemotherapy medication frequently used to treat various forms of cancer.
The purpose of this research was to examine if the administration of Arthrospira platensis …

In-vivo anticancer efficacy of self-targeted methotrexate-loaded polymeric nanoparticles in solid tumor-bearing rat

R Verma, V Rani, M Kumar - International Immunopharmacology, 2023 - Elsevier
Here, cytotoxicity and antitumor efficacy against a chemically (N-methyl-N-nitrosourea)
generated mammary tumor in rats were assessed using methotrexate-loaded chitosan …

[HTML][HTML] Luteolin improves nephropathy in hyperglycemic rats through anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms

LY Chen, HL Cheng, CK Liao, YH Kuan… - Journal of Functional …, 2023 - Elsevier
Hyperglycemia can also induce the production of free radicals and the progression of
inflammatory reactions. The aim of this study is to explore the potential anti-oxidant and anti …

Luteolin attenuates CCl4-induced hepatic injury by inhibiting ferroptosis via SLC7A11

Z Han, Batudeligen, H Chen, Narisu, Anda… - … Medicine and Therapies, 2024 - Springer
Abstract Background Luteolin (3, 4, 5, 7-tetrahydroxy flavone) is reported to strongly protect
from acute carbon tetrachloride (CCl4)-induced liver injury or fibrosis. Ferroptosis can be …