Our understanding of the functions of ceramide signaling has advanced tremendously over
the past decade. In this review, we focus on the roles and regulation of neutral …

Ceramide, a bioactive sphingolipid, is now at the forefront of cancer research. Classically,
ceramide is thought to induce death, growth inhibition, and senescence in cancer cells …

The hedgehog (Hh) signaling pathway is considered to be a major signal transduction
pathway during embryonic development, but it usually shuts down after birth. Aberrant Sonic …

Basal cell carcinoma (BCC) is the most common form of skin cancer, affecting more often
elderly patients, but sometimes even younger ones, particularly if immunocompromised or …

Hypothalamic tanycytes, radial glial cells that share many features with neuronal
progenitors, can generate small numbers of neurons in the postnatal hypothalamus, but the …

Studies over the past two decades have identified ceramide as a multifunctional central
molecule in the sphingolipid biosynthetic pathway. Given its diverse tumor suppressive …

Non-Small-Cell-Lung-Cancer (NSCLC) represents approximately 85% of all lung cancers
and remains poorly understood. While signaling pathways operative during organ …

Bioactive lipids are essential components of human cells and tissues. As discussed in this
review, the cancer lipidome is diverse and malleable, with the ability to promote or inhibit …

Abstract Neutral sphingomyelinase-2 (nSMase2) is a ceramide-generating enzyme that has
been implicated in growth arrest, apoptosis and exosome secretion. Although previous …

Purpose: The role of cholesterol biosynthesis in hedgehog pathway activity and progression
of hedgehog pathway medulloblastoma (Hh-MB) were examined in vivo. Statins, commonly …