MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian Ste20-like family of
serine/threonine kinases. MAP4Ks including MAP4K1/HPK1, MAP4K2/GCK, MAP4K3/GLK …

Medulloblastoma is the most common malignant brain cancer in pediatrics consisting of four
molecular subgroups, namely wingless (WNT), sonic hedgehog (SHH), Group 3, and Group …

Collective cell migration is fundamental in development, wound healing, and metastasis.
During Drosophila oogenesis, border cells (BCs) migrate collectively inside the egg …

We report 21 families displaying neurodevelopmental differences and multiple congenital
anomalies while bearing a series of rare variants in mitogen-activated protein kinase kinase …

The invasion of cancer cells into surrounding tissue and the vasculature is essential for
tumor metastasis. Increasing evidence indicates that hepatocyte growth factor (HGF) …

The finely tuned integration of intra-and extracellular cues by components of the mitogen-
activated protein kinase (MAPK) signaling pathways controls the mutually exclusive …

MAP4K4 is associated with increased motility and reduced proliferation in tumor cells, but
the regulation of this dichotomous functionality remained elusive. We find that MAP4K4 …

Cetuximab in combination with an irinotecan‐containing regimen is a standard treatment in
patients with KRAS wild‐type (KRAS WT), metastatic colorectal cancer (mCRC). We …

Overexpression of the serine/threonine kinase GLK/MAP4K3 in human lung cancer is
associated with poor prognosis and recurrence, however, the role of GLK in cancer …

The microenvironment shapes cell behavior and determines metastatic outcomes of tumors.
We addressed how microenvironmental cues control tumor cell invasion in pediatric …