Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

VP Torchilin - Nature reviews Drug discovery, 2014 - nature.com
The use of nanoparticulate pharmaceutical drug delivery systems (NDDSs) to enhance the
in vivo effectiveness of drugs is now well established. The development of multifunctional …

Current trends in the use of liposomes for tumor targeting

PP Deshpande, S Biswas, VP Torchilin - Nanomedicine, 2013 - Taylor & Francis
The use of liposomes for drug delivery began early in the history of pharmaceutical
nanocarriers. These nanosized, lipid bilayered vesicles have become popular as drug …

Treating metastatic cancer with nanotechnology

A Schroeder, DA Heller, MM Winslow… - Nature Reviews …, 2012 - nature.com
Metastasis accounts for the vast majority of cancer deaths. The unique challenges for
treating metastases include their small size, high multiplicity and dispersion to diverse organ …

The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors

H Hatakeyama, H Akita, H Harashima - … and pharmaceutical bulletin, 2013 - jstage.jst.go.jp
Gene and nucleic acid therapy is expected to play a major role in the next generation of
agents for cancer treatment. We have recently developed a multifunctional envelope-type …

Targeting nanoparticles to cancer

M Wang, M Thanou - Pharmacological research, 2010 - Elsevier
Nanotechnology applications in medicine, termed as nanomedicine, have introduced a
number of nanoparticles of variable chemistry and architecture for cancer imaging and …

Pharmacokinetics and biodistribution of nanoparticles

SD Li, L Huang - Molecular pharmaceutics, 2008 - ACS Publications
Nanoparticles show their promise for improving the efficacy of drugs with a narrow
therapeutic window or low bioavailability, such as anticancer drugs and nucleic acid-based …

Lipid-based nanoparticle technologies for liver targeting

R Böttger, G Pauli, PH Chao, NAL Fayez… - Advanced drug delivery …, 2020 - Elsevier
Liver diseases such as hepatitis, cirrhosis, and hepatocellular carcinoma are global health
problems accounting for approximately 800 million cases and over 2 million deaths per year …

Cytokines as biomarkers of nanoparticle immunotoxicity

M Elsabahy, KL Wooley - Chemical Society Reviews, 2013 - pubs.rsc.org
Nanoscale objects, whether of biologic origin or synthetically created, are being developed
into devices for a variety of bionanotechnology diagnostic and pharmaceutical applications …

More effective nanomedicines through particle design

J Wang, JD Byrne, ME Napier, JM DeSimone - small, 2011 - Wiley Online Library
Nanomedicine is an emerging field that applies concepts in nanotechnology to develop
novel diagnostics and therapies. Physical and chemical properties of particles, including …

Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy

Y Chen, X Zhu, X Zhang, B Liu, L Huang - Molecular therapy, 2010 - cell.com
Targeted delivery of RNA-based therapeutics for cancer therapy remains a challenge. We
have developed a LPH (liposome-polycation-hyaluronic acid) nanoparticle formulation …