Aiming drug discovery at lysophosphatidic acid targets

G Tigyi - British journal of pharmacology, 2010 - Wiley Online Library
Lysophosphatidic acid (LPA, 1‐radyl‐2‐hydroxy‐sn‐glycero‐3‐phosphate) is the prototype
member of a family of lipid mediators and second messengers. LPA and its naturally …

Human hair and the impact of cosmetic procedures: a review on cleansing and shape-modulating cosmetics

CF Cruz, C Costa, AC Gomes, T Matamá… - Cosmetics, 2016 - mdpi.com
Hair can be strategically divided into two distinct parts: the hair follicle, deeply buried in the
skin, and the visible hair fiber. The study of the hair follicle is mainly addressed by biological …

Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6

K Yanagida, K Masago, H Nakanishi, Y Kihara… - Journal of Biological …, 2009 - ASBMB
p2y5 is an orphan G protein-coupled receptor that is closely related to the fourth
lysophosphatidic acid (LPA) receptor, LPA 4. Here we report that p2y5 is a novel LPA …

LPA‐producing enzyme PA‐PLA1α regulates hair follicle development by modulating EGFR signalling

A Inoue, N Arima, J Ishiguro, GD Prestwich… - The EMBO …, 2011 - embopress.org
Recent genetic studies of human hair disorders have suggested a critical role of
lysophosphatidic acid (LPA) signalling in hair follicle development, mediated by an LPA …

Biology and genetics of hair

Y Shimomura, AM Christiano - Annual review of genomics and …, 2010 - annualreviews.org
The mammalian hair follicle (HF) is a complex structure composed of several distinct cell
layers. The HF is an ectodermal appendage that resides in the skin, and unlike other tissues …

Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture

Y Shimomura, M Wajid, L Petukhova, M Kurban… - The American Journal of …, 2010 - cell.com
Autosomal-dominant woolly hair (ADWH) is a rare disorder characterized by tightly curled
hair. The molecular basis of ADWH has not previously been reported. In this study, we …

Update of recent findings in genetic hair disorders

R Hayashi, Y Shimomura - The Journal of Dermatology, 2022 - Wiley Online Library
Genetic hair disorders, although unusual, are not very rare, and dermatologists often have
opportunities to see patients. Significant advances in molecular genetics have led to …

Towards broadening Forensic DNA Phenotyping beyond pigmentation: Improving the prediction of head hair shape from DNA

E Pośpiech, Y Chen, M Kukla-Bartoszek… - Forensic Science …, 2018 - Elsevier
Human head hair shape, commonly classified as straight, wavy, curly or frizzy, is an
attractive target for Forensic DNA Phenotyping and other applications of human appearance …

[HTML][HTML] A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis

A Fujimoto, M Farooq, H Fujikawa, A Inoue… - Journal of Investigative …, 2012 - Elsevier
Woolly hair (WH) is an abnormal variant of tightly curled hair, which is frequently associated
with hypotrichosis. Non-syndromic forms of WH can show either autosomal-dominant WH …

The biology of hair diversity

GE Westgate, NV Botchkareva… - International journal of …, 2013 - Wiley Online Library
Hair diversity, its style, colour, shape and growth pattern is one of our most defining
characteristics. The natural versus temporary style is influenced by what happens to our hair …