The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …

Extracellular vesicles are a heterogeneous group of cell-derived membranous structures
comprising exosomes and microvesicles, which originate from the endosomal system or …

Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide.
However, the current pharmacological approaches used to treat OA are largely palliative …

Cells can detect and react to the biophysical properties of the extracellular environment
through integrin-based adhesion sites and adapt to the extracellular milieu in a process …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a
problem with a heavy economic burden, which has been increasing in prevalence as …

The extracellular matrix (ECM) is the noncellular component present within all tissues and
organs, and provides not only essential physical scaffolding for the cellular constituents but …

Adipose tissue is a central metabolic organ. Unlike other organs, adipose tissue is
compartmentalized into individual depots and distributed throughout the body. These …

Urokinase-type plasminogen activator receptor (uPAR) expression is elevated during
inflammation and tissue remodelling and in many human cancers, in which it frequently …

Tumor progression involves the ability of cancer cells to communicate with each other and
with neighboring normal cells in their microenvironment. Microvesicles (MV) derived from …