Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Mitochondria are one of the most exhaustively investigated organelles in the cell and most
attention has been paid to the components of the mitochondrial electron transport chain …

Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria
are essential organelles responsible for numerous physiologic processes, such as energy …

Deferoxamine (DFO) represents a widely used iron chelator for the treatment of iron
overload. Here we describe the use of mitochondrially targeted deferoxamine (mitoDFO) as …

Previous studies have shown that mitochondria play core roles in not only cancer stem cell
(CSC) metabolism but also the regulation of CSC stemness maintenance and differentiation …

Mitochondria are crucial cellular organelles. Under extracellular stimulations, mitochondria
undergo constant fusion and fission dynamics to meet different cellular demands …

Under aerobic conditions, mitochondrial oxidative phosphorylation (OXPHOS) converts the
energy released by nutrient oxidation into ATP, the currency of living organisms. The whole …

Breast cancer is the most common cancer among females and the leading cause of cancer-
related deaths. Approximately 70% of breast cancers are estrogen receptor (ER) positive. An …

To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …

Simple Summary Mitochondria are well known for being the powerhouses of the cell—
whether the cell is normal or cancerous. Moreover, they can move, split, fuse themselves, or …