Identification of the thyroid transcription factors (TTFs), NKX2-1, FOXE1, PAX8 and HHEX,
has considerably advanced our understanding of thyroid development, congenital thyroid …

Approximately 90% of thyroid cancers are differentiated (DTCs) and have papillary, follicular
or Hürthle cell morphology. Although treatment with surgery and radioactive iodine (I-131; …

The presence of differentiated thyroid cells in thyroid cancer is critical for the antitumor
response to radioactive iodide treatment, and loss of the differentiated phenotype is a key …

The transcription factor Pax8, a member of the Paired-box gene family, is a critical regulator
required for proper development and differentiation of thyroid follicular cells. Despite being …

Background Ovarian cancer is the third most common cause of death among gynecologic
malignancies worldwide. Understanding the biology and molecular pathogenesis of ovarian …

Abstract Background The transcription factor Pax8 is essential for the differentiation of
thyroid cells. However, there are few data on genes transcriptionally regulated by Pax8 other …

Background Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital
hypothyroidism (CH) in both humans and mice due to decreased expression of several …

Understanding the biology and molecular pathogenesis of ovarian epithelial cancer (EOC)
is key to developing improved diagnostic and prognostic indicators and effective therapies …

To explore the molecular mechanism of insulin on proliferation and differentiation of MC3T3‐
E1 cell under high glucose conditions. We first investigated the effect of different …

The transcription factor Pax8 is already known to be essential at very early stages of mouse
thyroid gland development, before the onset of thyroid hormone production. In this paper we …