Sickle cell disease is the most common hemoglobinopathy among humans. As the condition
promotes susceptibility to infections, chronic inflammation, and hypercoagulability disorders …

Background Sickle cell disease is a fatal systemic condition characterized by acute painful
episodes, persistent anemia, ongoing organ damage, organ infarction, and a markedly …

In this paper the authors provide evidence that hydroxyurea (hydroxycarbamide) interacts
with α7 nicotinic acetylcholine receptor, exerts anti-inflammatory and pro-survival effect …

Intravascular hemolysis (IVH) occurs in numerous inherited and acquired disorders,
including sickle cell disease (SCD), malaria and sepsis. These diseases display unique …

A boron-nitrogen (BN)-doped graphene (G) was assessed in this work for approaching the
drug delivery of hydroxyurea (HU) anticancer. Density functional theory (DFT) calculations …

Hydroxyurea and pyridostigmine repurposed for treating Covid-19 multi-systems dysfunctions
Page 1 AIMS Medical Science, 10(2): 118–129. DOI: 10.3934/medsci.2023010 Received: 03 …

Abstract SARS-Cov-2, the virus causing COVID-19, penetrates host target cells via the
receptor of angiotensin-converting enzyme 2 (ACE2). Disrupting the virus interaction with …

Coronavirus disease 2019 (COVID-19) is still an active global public health issue. Although
vaccines and therapeutic options are available, some patients experience severe conditions …

Based on a large use over more than 30 years, in adults and children, Hydroxyurea (HU)
has emerged as the primary disease-modifying therapy for sickle cell disease (SCD) with …