All chemical transformations pass through an unstable structure called the transition state,
which is poised between the chemical structures of the substrates and products. The …

Experimental analysis of enzymatic transition-state structures uses kinetic isotope effects
(KIEs) to report on bonding and geometry differences between reactants and the transition …

This review focuses on the chemistry performed by base excision repair (BER) enzymes,
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …

Genetic defects in human purine nucleoside phosphorylase cause T-cell deficiency as the
major phenotype. It has been proposed that efficient inhibitors of the enzyme might intervene …

O-GlcNAcase catalyzes the cleavage of β-O-linked 2-acetamido-2-deoxy-β-d-
glucopyranoside (O-GlcNAc) from serine and threonine residues of post-translationally …

Recent studies have shown that Plasmodium falciparum is sensitive to a purine salvage
block at purine nucleoside phosphorylase (PNP) and that human PNP is a target for T-cell …

The incredible catalytic rate enhancements caused by enzymes led Linus Pauling (1) to
suggest that enzymes bind tightly to substrates distorted toward the transition state, thereby …

In this study, a series of new 3-((5-(4-(5-substitue-1H-benz [d] imidazol-2-yl) phenyl)-1, 3, 4-
oxadiazol-2-yl) thio)-1-phenyl propane-1-on (4a-4d) derivatives has been designed and …

Recently, the interest in targeting metalloenzymes is obviously growing for halting various
tumor progression events and surmounting the resistance due to routine chemotherapy …

Kinetic isotope effects and computational chemistry have defined the transition state
structures for several members of the N-ribosyltransferase family. Transition state analogues …