Programmed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene
and is constitutively expressed on the surface of immune cells. As a receptor and immune …

Simple Summary Given its huge impact on global health, lung cancer remains a major
diagnostic and therapeutic challenge. However, much has been achieved, and this review …

Lung cancer is one of the most prevalent malignancies worldwide, contributing to over a
million cancer-related deaths annually. Despite extensive research investigating the genetic …

Purpose: The immune responses of natural killer (NK) cells against cancer cells vary by
patient. Killer Ig-like receptors (KIRs), which are some of the major receptors involved in …

Endometrial cancer (EC) constitutes more than half of all genital cancers in women, with an
increasing incidence in different countries. Natural killer cells (NK cells) are kinds of innate …

Introduction Human leukocyte antigen (HLA) polymorphisms have been associated with the
development of various autoimmune diseases, as well as malignant neoplasms. Non …

Colorectal cancer (CRC) is the most common cause of cancer-related mortality globally. It
ranks as the most common cancer among men and the third most prevalent among women …

Abstract Objective Natural Killer cells activation depends on the interaction with killer cell
immunoglobin-like receptors (KIRs), which bind the peptide-binding region of several class-I …

Immune cells such as Natural Killer (NK) cells play a central role in immunosurveillance,
preserving the physiological integrity of tissues by fighting infection and combating tumor …

Abstract Human Natural Killer (NK) cells are heterogeneous lymphocytes regulated by
variegated arrays of germline-encoded activating and inhibitory receptors. They acquire the …