A common limitation of recombinant protein production in bacteria is the formation of
insoluble protein aggregates known as inclusion bodies. The propensity of a given protein to …

Since the introduction of recombinant protein expression in the second half of the 1970s, the
growth of the biopharmaceutical field has been rapid and protein therapeutics has come to …

Protein aggregation is a major bottleneck during the bacterial production of recombinant
proteins. In general, the induction of gene expression at sub‐optimal growth temperatures …

Understanding the structure, functionalities and biology of functional amyloids is an issue of
emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria …

Increasing evidence indicates that protein aggregation in bacteria does not necessarily
imply loss of biological activity. Here, we have investigated the effect of growth-temperature …

Background For a long time IBs were considered to be inactive deposits of accumulated
target proteins. In our previous studies, we discovered IBs containing a high percentage of …

Many muscular diseases result from abnormal organization of connective tissue and/or
collagen network formation. Only a few molecular imaging techniques are able to analyze …

Background In recent years, it has been gradually realized that bacterial inclusion bodies
(IBs) could be biologically active. In particular, several proteins including green fluorescent …

The accumulation of aggregated protein in the cell is associated with the pathology of many
diseases and constitutes a major concern in protein production. Intracellular aggregates …

Light chain (AL) amyloidosis, caused by deposition of amyloidogenic immunoglobulin light
chains (LCs), is the most common systemic form in industrialized countries. Still open …