Adverse drug reactions of acetylcholinesterase inhibitors in older people living with dementia: a comprehensive literature review

S Ruangritchankul, P Chantharit… - … and clinical risk …, 2021 - Taylor & Francis
The rising of global geriatric population has contributed to increased prevalence of
dementia. Dementia is a neurodegenerative disease, which is characterized by progressive …

The epidemiology of polypharmacy in older adults: register-based prospective cohort study

L Morin, K Johnell, ML Laroche, J Fastbom… - Clinical …, 2018 - Taylor & Francis
Objective Polypharmacy is the concomitant use of several drugs by a single person, and it
increases the risk of adverse drug-related events in older adults. Little is known about the …

Factors associated with polypharmacy and the high risk of medication-related problems among older community-dwelling adults in European countries: a longitudinal …

L Ye, J Yang-Huang, CB Franse, T Rukavina… - BMC geriatrics, 2022 - Springer
Background Polypharmacy can be defined as using five or more medications
simultaneously.“Medication-related problems”, an extension of polypharmacy, includes …

The composition of polypharmacy: a register-based study of Swedes aged 75 years and older

JW Wastesson, A Cedazo Minguez, J Fastbom… - PloS one, 2018 - journals.plos.org
Background Polypharmacy is common among older adults. However, little is known about
the composition of polypharmacy: which are the most frequently used drugs, and how much …

Drug–drug interactions involving CYP3A4 and p-glycoprotein in hospitalized elderly patients

P Gallo, A De Vincentis, C Pedone, A Nobili… - European journal of …, 2019 - Elsevier
Polypharmacy is very common in older patients and may be associated with drug-drug
interactions. Hepatic cytochrome P450 (notably 3A4 subtype, CYP3A4) is a key enzyme …

Effectiveness and patient safety of platelet aggregation inhibitors in the prevention of cardiovascular disease and ischemic stroke in older adults–a systematic review

M Meinshausen, A Rieckert, A Renom-Guiteras… - BMC geriatrics, 2017 - Springer
Background Platelet aggregation inhibitors (PAI) are among the most frequently prescribed
drugs in older people, though evidence about risks and benefits of their use in older adults is …

Characterising polypharmacy in the very old: Findings from the Newcastle 85+ Study

LE Davies, A Kingston, A Todd, B Hanratty - PLoS One, 2021 - journals.plos.org
Background Polypharmacy is potentially harmful and under-researched amongst the fastest
growing subpopulation, the very old (aged≥ 85). We aimed to characterise polypharmacy …

Modifications in drug adherence after switch to fixed-dose combination of perindopril/amlodipine in clinical practice. Results of a large-scale Italian experience. The …

L Degli Esposti, V Perrone, C Veronesi… - … medical research and …, 2018 - Taylor & Francis
Objective: The purpose of this study was to assess the changes in adherence to treatment, in
patients who switched from perindopril and/or amlodipine as a monotherapy (single-pill …

Polypharmacy in polish older adult population—a cross-sectional study: results of the PolSenior project

A Neumann-Podczaska, S Tobis, D Antimisiaris… - International journal of …, 2022 - mdpi.com
Polypharmacy is a challenging issue in geriatrics. The aim of the study was to characterize
correlates of polypharmacy in the PolSenior project. The PolSenior project, was a …

Medication use among older people in Europe: Implications for regulatory assessment and co‐prescription of new medicines

A Strampelli, F Cerreta, K Vučić - British journal of clinical …, 2020 - Wiley Online Library
Aims The aim of this study was to elucidate drug prescription patterns in older European
people with the objective to support regulatory contextualisation of (1) the suitability of …