FOXK transcription factors: regulation and critical role in cancer

Y Liu, W Ding, H Ge, M Ponnusamy, Q Wang, X Hao… - Cancer letters, 2019 - Elsevier
Growing evidence suggests that alterations of gene expression including expression and
activities of transcription factors are closely associated with carcinogenesis. Forkhead Box …

[HTML][HTML] The untold stories of the speech gene, the FOXP2 cancer gene

MJ Herrero, Y Gitton - Genes & cancer, 2018 - ncbi.nlm.nih.gov
FOXP2 encodes a transcription factor involved in speech and language acquisition. Growing
evidence now suggests that dysregulated FOXP2 activity may also be instrumental in human …

The influence of various regions of the FOXP2 sequence on its structure and DNA-binding function

M Thulo, MA Rabie, N Pahad, HL Donald… - Bioscience …, 2021 - portlandpress.com
FOX proteins are a superfamily of transcription factors which share a DNA-binding domain
referred to as the forkhead domain. Our focus is on the FOXP subfamily members, which are …

Unraveling the interplay between the leucine zipper and forkhead domains of FOXP2: Implications for DNA binding, stability and dynamics

CM Perumal, M Thulo, S Buthelezi… - Proteins: Structure …, 2024 - Wiley Online Library
FOXP2 is a transcription factor associated with speech and language. Like other FOX
transcription factors, it has a DNA binding region called the forkhead domain (FHD). This …

A phosphomimetic study implicates Ser557 in regulation of FOXP2 DNA binding

A Blane, HW Dirr, S Fanucchi - The protein journal, 2018 - Springer
FOXP2 is a transcription factor expressed in multiple tissues during embryonic development.
FOXP2 regulates transcription by binding to DNA at its DNA binding domain, the forkhead …

The forkhead domain hinge-loop plays a pivotal role in DNA binding and transcriptional activity of FOXP2

G Morris, S Stoychev, P Naicker, HW Dirr… - Biological …, 2018 - degruyter.com
Forkhead box (FOX) proteins are a ubiquitously expressed family of transcription factors that
regulate the development and differentiation of a wide range of tissues in animals. The …

A conserved cation binding site in the DNA binding domain of forkhead box transcription factors regulates DNA binding by FOXP2

G Morris, N Pahad, HW Dirr, S Fanucchi - Archives of biochemistry and …, 2018 - Elsevier
FOXP2 is a transcriptional repressor involved in development of the human brain and is the
first gene product to be linked to the evolution of human speech. FOXP2 belongs to the FOX …

[PDF][PDF] Investigating FOXP2 dynamics, stability, and DNA-binding capabilities

C Perumal - 2023 - wiredspace.wits.ac.za
All forkhead box (FOX) transcription factors share a conserved DNA-binding domain called
the forkhead domain. They regulate gene expression in different organisms and have …

[PDF][PDF] Identification and characterisation of the interaction between FOXP2 and the ligand binding domain of oestrogen receptor α

AY Lakhi - 2023 - wiredspace.wits.ac.za
ABSTRACT Forkhead box P2 (FOXP2) regulates the expression of various genes and is
associated with language and speech, neural development and outgrowth, and cancer. As …

[PDF][PDF] A bacterial surface display platform for the discovery of cytosine modification readers from cDNA libraries

D Schiller - 2023 - eldorado.tu-dortmund.de
8.1 Genome organization and composition in eukaryotes 8.1. 1 Storage of genetic
information in deoxyribonucleic acid sequences All living organisms on our planet …