Arginine methylation is a common post-translational modification functioning as an
epigenetic regulator of transcription and playing key roles in pre-mRNA splicing, DNA …

Arginine methylation is a ubiquitous post-translational modification. Three predominant
types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric …

The field of chromatin biology has been advancing at an accelerated pace. Recent
discoveries of previously uncharacterized sites and types of post-translational modifications …

Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), is challenging to model in
mice. Not only is it a contiguous gene syndrome spanning 35 Mb of the long arm of Hsa21 …

A generalizable strategy with programmable site specificity for in situ profiling of histone
modifications on unperturbed chromatin remains highly desirable but challenging. We …

PRMT1, the major protein arginine methyltransferase in mammals, catalyzes
monomethylation and asymmetric dimethylation of arginine side chains in proteins. Initially …

Studies over the past four decades have elucidated the role of Wnt/β-catenin mediated
regulation in cell proliferation, differentiation and migration. These processes are …

Transcriptional deregulation has a vital role in glioblastoma multiforme (GBM). Thus,
identification of epigenetic modifiers essential for oncogenic transcriptional programs is a …

PRMT2 belongs to the protein arginine methyltransferase (PRMT) family, which catalyzes
the arginine methylation of target proteins. As a type I enzyme, PRMT2 produces asymmetric …

Serial capture affinity purification (SCAP) is a powerful method to isolate a specific protein
complex. When combined with cross-linking mass spectrometry and computational …