The mangrove forests are a complex ecosystem, and the microbial communities in
mangrove sediments play a critical role in the biogeochemical cycles of mangrove …

Bacterial infections pose a significant clinical burden on global health. The growing
incidence of drug-resistant pathogens highlights the critical necessity to identify and isolate …

A strategy integrating in silico molecular docking with LXRα and phenotypic assays was
adopted to discover anti-hypercholesterolemia agents in a small library containing 205 …

Two new chlorinated metabolites, 8-chlorine-5-hydroxy-2, 3-dimethyl-7-methoxychromone
(1) and 3, 4-dichloro-1 H-pyrrole-2, 5-dione (3), and eight known compounds (2 and 4–9) …

Five undescribed butenolides including two pairs of enantiomers,(+)-asperteretal G (1a),(−)-
asperteretal G (1b),(+)-asperteretal H (2a),(−)-asperteretal H (2b), asperteretal I (3), and para …

To discover bioactive natural products from mangrove sediment-derived microbes, a
chemical investigation of the two Beibu Gulf-derived fungi strains, Talaromyces sp. SCSIO …

A new trithiodiketopiperazine derivative, adametizine C (1), and five new alkane derivatives
(7–11), were isolated from the mangrove sediment–derived fungus Penicillium ludwigii …

New carboxamides,(±)-vochysiamide C (1) and (+)-vochysiamide B (2), and a new
polyketide, 4 S, 3a S, 9a R-3a, 9a-deoxy-3a hydroxy-1-dehydroxyarthrinone (3), were …

Figure S1: Molecular docking of Orlistat with PL (1LPB and 1F6W) and the scores. 2 Figure
S2: 1H NMR spectrum of 1 (CD3OD, 700 MHz). 3 Figure S3: 13C NMR spectrum of 1 …

Despite the increasing availability of modern treatments, including personalized therapies,
there is a strong need to search for new drugs that will be effective in the fight against …