Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

The development of multicellular organisms is controlled by highly dynamic molecular and
cellular processes organized in spatially restricted patterns. Recent advances in …

The Erk mitogen-activated protein kinase plays diverse roles in animal development. Its
widespread reuse raises a conundrum: when a single kinase like Erk is activated, how does …

Reprogramming cell fate during the first stages of embryogenesis requires that
transcriptional activators gain access to the genome and remodel the zygotic transcriptome …

Metazoan embryos develop from a single cell into three-dimensional structured organisms
while groups of genetically identical cells attain specialized identities. Cells of the …

Cells receive enormous amounts of information from their environment. How they act on this
information—by migrating, expressing genes, or relaying signals to other cells—comprises …

Predicting how interactions between transcription factors and regulatory DNA sequence
dictate rates of transcription and, ultimately, drive developmental outcomes remains an open …

Developmental patterning networks are regulated by multiple inputs and feedback
connections that rapidly reshape gene expression, limiting the information that can be …

The way in which interactions between mechanics and biochemistry lead to the emergence
of complex cell and tissue organization is an old question that has recently attracted …